Curr Biol：高度集中注意力可有效缓解疼痛感

近日，刊登在国际著名杂志Cell的子刊Current Biology上的一篇深入研究报告指单单，利用潜意识干扰（好在）的法则可以使得眼部过重，然而这种眼部加剧过重的振荡并不表现在头部。这项深入研究见到是基于适用高分辨率的肾脏；也造影超声应用（fMRI应用），对人们由于高温导致的眼部水平开展深入研究，深入研究推断出，潜意识干扰毕竟可以在本部眼部处理早期抑制眼部瞬时的传布。来自汉堡-埃谢施泰因大学的大学的深入学者Christian Sprenger指出，这种现像并不仅仅是一种潜意识现像，而是一种活跃的骨骼肌机制，可以提高从脑上升至大脑高级地带的眼部瞬时。

这种振荡涉及到了抑制的类颗粒，这种颗粒产生自大脑，在过重眼部的过程中扮演着极为重要角色。深入研究人员让行动者分别已完成一个非常简单或者一个更容易的记忆性护航，需要他们记得信里的文字段落，同时给行动者胳膊上加诸高温。开展更容易护航的行动者越发心烦意乱时，他们就会感到更为大的眼部，通过fMRI应用看出单单这些行动者的脑地带活性越发更为低，fMRI有时候是用来测定大脑活性的忽略。

Sprenger和他的同事然后重复了试验中，这次他们给与行动者一种药品-钠洛酮（抗休克的平庸药品，可以阻挡药品的振荡）或者都可的盐水流过，结果显示，相比只流过都可盐水的行动者，适用药品拮抗剂的行动者由于注意力集中于，导致的眼部加剧提高了40%，因此声称抑制的扮演着极为重要作用。

深入学者的见到推断出了潜意识过程可以透彻地忽略人们的眼部经历，并且对于医学也有极其极为重要的涵义。深入学者指出，我们的深入研究见到给眼部疾病治疗提供了潜意识行为治疗的法则。（生物谷：T.Shen编译）

doi:10.1016/j.cub.2012.04.006PMC:PMID:

Attention Modulates Spinal Cord Responses to Pain

Christian Sprenger1, , , Falk Eippert1, Jürgen Finsterbusch1, Ulrike Bingel1, 2, Michael Rose1, Christian Büchel1

Reduced pain perception while being distracted from pain is an everyday example of how cognitive processes can interfere with pain perception [ [1], [2], [3], [4] and [5]]. Previous neuroimaging studies showed distraction-related modulations of pain-driven activations in various cortical and subcortical brain regions [ [6], [7], [8], [9], [10] and [11]], but the precise neuronal mechanism underlying this phenomenon is unclear. Using high-resolution functional magnetic resonance imaging of the human cervical spinal cord in combination with thermal pain stimulation and a well-established working memory task [12], we demonstrate that this phenomenon relies on an inhibition of incoming pain signals in the spinal cord. Neuronal responses to painful stimulation in the dorsal horn of the corresponding spinal segment were significantly reduced under high working memory load compared to low working memory load. At the individual level, reductions of neuronal responses in the spinal cord predicted behioral pain reductions. In a subsequent behioral experiment, using the opioid antagonist naloxone in a double-blind crossover design with the same paradigm, we demonstrate a substantial contribution of endogenous opioids to this mechanism. Taken together, our results show that the reduced pain experience during mental distraction is related to a spinal process and involves opioid neurotransmission.